Nel nostro quotidiano siamo spesso circondati da prodotti definiti “dietetici”, “acalorici”, “zero”, “senza zuccheri”, che ci illudono riguardo ai potenziali ed inesistenti effetti benefici sull’organismo. Quanti di voi possono dire di non aver mai comprato prodotti di questo tipo? Sicuramente molto pochi. Il marketing e i mass media quotidianamente ci invogliano a comprare questi alimenti, illudendoci che, grazie ad essi, possiamo arginare il problema dei tanto demonizzati, giustamente, zuccheri responsabili dell’aumento, a lungo andare, della massa grassa. In realtà, l’assenza di questi nutrienti in gomme, marmellate ed altri prodotti affini non si giustifica assaggiando questi prodotti. Vi è infatti un sapore molto simile al corrispettivo prodotto dove troviamo zucchero all’interno. Questo viene giustificato dalla presenza dei cosiddetti “dolcificanti”, conosciuti anche come “edulcoranti”. Questi sono di varia natura. Gli idrati di carbonio (calorici) sono saccarosio e fruttosio (zuccheri ordinari), xilitolo e mannitolo (polioli): essi hanno un potere dolcificante simile al saccarosio e sembra stimolino, in modo analogo al comune zucchero, l’insulina. Gli edulcoranti intensi (dolcificanti ad alto effetto e quindi ipocalorici) si dividono invece in naturali ed artificiali. Tra i primi troviamo le proteine come la taumatina e miracolina ed i glicosidi stevioside e glicirrizina, mentre dei secondi fanno parte aspartame, saccarina, acesulfame K e ciclamato. Questi ultimi, in virtù del potere dolcificante molto superiore al saccarosio, sono considerati ipocalorici e non hanno un effetto diretto sull’insulina, nonostante studi recenti dimostrino che il loro effetto si manifesti in modo indiretto. Cosa fa l’insulina? E’ un ormone secreto dal pancreas in seguito all’assunzione di carboidrati. In fase postprandiale, infatti, vi è una rapida e sostenuta secrezione di insulina, necessaria per limitare l’innalzamento della glicemia. Ormone antagonista è invece il glucagone che, in caso di digiuno, stimola la scissione del glicogeno (riserva di zuccheri) al fine di poter garantire energia alle cellule per le proprie funzioni. L’assunzione orale di glucosio induce una riduzione dei livelli di glucagone che, agendo in modo coordinato con l’incremento dei livelli di insulina, determina una riduzione della produzione epatica di glucosio. Quando si assumono carboidrati, viene secreto dalle cellule dell’intestino un ormone, GLP-1, che permette la riduzione della produzione di glucagone ed aumenta invece quella di insulina, facendo diminuire l’appetito. Tale ormone, quindi, fa in modo che tutto sia pronto quando questi zuccheri sono presenti nel sangue. Questo meccanismo regolatorio viene meno nei pazienti diabetici, dove la mancanza di insulina non permette una corretta omeostasi glicemica. Ecco perché è necessaria una somministrazione esterna. L’insulina, oltre che a riportare il livello di glucosio ematico in condizioni standard, stimola, a fronte di un rapido innalzamento della glicemia, causato dall’ingestione di un pasto ricco in carboidrati, la produzione dagli zuccheri in eccesso di grassi, che vanno ad incrementare il tessuto adiposo, creando così aumento della massa grassa in zone per noi “scomode”. Se miele, saccarosio e fruttosio si è visto che comportano l’attivazione di questo effetto nel nostro organismo, si è sempre più convinti che anche i dolcificanti artificiali possano causare questo effetto in modo, però, indiretto. Vediamo come fanno. Quando si mangia o si beve, le molecole del cibo o della bibita entrano in contatto con i recettori del gusto. In tal modo, il cervello riceve segnali che consentono di individuare il gusto corrispondente a ciò che si ingerisce. Ci sono infatti tre nervi che raccolgono le informazioni gustative: Il nervo vago, il nervo glossofaringeo ed Il nervo facciale. Le fibre nervose arrivano, quindi, grazie ad essi alla porzione craniale del nucleo del fascicolo solitario (nucleo gustativo) ed attraverso il lemnisco mediale arrivano al talamo e poi alla corteccia gustativa, comunicando al cervello che il cibo ingerito è dolce. Oltre che sulla lingua, possediamo recettori del gusto anche nel tratto gastrointestinale e nel tratto respiratorio. A cosa servono? Sicuramente non sono utili per distinguere il sapore del cibo, ma nel primo caso sembra siano utili a guidare la digestione e nel secondo sono utili per difenderci da sostanze estranee inalate e potenzialmente tossiche. In particolare, i recettori per il gusto dolce (TAS1R) dopo aver rilevato queste sostanze, favoriscono la secrezione di GLP-1 (glucagon-like-peptide-1), che a sua volta stimola il rilascio di insulina promuovendo l’assorbimento di glucosio. L’attivazione di tali recettori guida, inoltre, la sintesi e l’inserimento dei trasportatori del glucosio SGLT-1 e GLUT2 nelle membrane delle cellule intestinali facilitando l’assorbimento di glucosio dal lume all’interno dell’enterocita (cellula intestinale) e dall’interno verso il circolo sanguigno. Negli ultimi anni si è scoperto che questo effetto, oltre che essere mediato dai zuccheri comuni, è prerogativa anche dei dolcificanti ipocalorici. Questo significa quindi che anche se ci vogliono far passare questi alimenti come privi di zuccheri, quali sono, le loro componenti esercitano un effetto del tutto analogo, che porta comunque alla secrezione di insulina. Il che significa che assumendo continuamente bibite “zero” e prodotti senza zuccheri in grandi quantità comunque si favorisce la lipogenesi dei carboidrati in eccesso introdotti. Cosa fare quindi? Diciamo che come sempre non ci sta la bacchetta magica che risolve tutto, il “cosa fare” lo dobbiamo trovare dentro di noi, cambiando il nostro stile di vita, le nostre abitudini. Questo significa abituarsi a prendere il caffè amaro, evitare di dolcificare la frutta che contiene già in sé zucchero (fruttosio), cercare il più possibile di fare una dieta il più equilibrata possibile, introducendo sempre nuovi alimenti e non fossilizzarsi solo e solamente sugli stessi. Evitare, inoltre, tutti gli alimenti che si pensano potenzialmente benefici solo perché nella copertina, appositamente studiata per attirare la nostra attenzione, ci siano diciture ingannevoli. Qualora si scelga di dolcificare con lo zucchero di canna, rispetto al comune saccarosio, bisogna ricordarsi che cambia poco, non è il colore che fa la differenza, perché fondamentalmente di differenza ce ne sta davvero poca. L’uso di alcuni di questi dolcificanti acalorici si è visto che interferisce con i farmaci usati da persone affette da diabete, ipertensione e cariopatie. Sembra, inoltre, che sviluppino i meccanismi molecolari coinvolti nello sviluppo dell’obesità, per questi sono sconsigliati nei primi anni di vita e che alcuni di questi come saccarina ed asportame possano indurre, a lungo andare, addirittura anche cancerogenicità. Concludiamo dicendo che anche in questo caso non ci sono divieti di assunzione, ma importante è sottolineare il fatto che ognuno è artefice del proprio destino ed in base alle proprie scelte può veramente inficiare sulla propria salute e sulla propria vita.
FRANCESCO SERAFINI
Biotecnologo con laurea magistrale in Biologia Cellulare e Molecolare presso l’Università degli Studi della Tuscia e specializzando in “Scienza dell’Alimentazione e Nutriterapia” presso l’Università degli Studi della Tuscia. Ha frequentato il corso di “ Alimentazione pratica nello sportivo” e “Nutrizione ed integrazione nel paziente oncologico II ” presso Scuola di Nutrizione Salernitana. Si è interessato nella sua carriera universitaria di “Checkpoint immunologici e regolazione della risposta immune. Blocco del CTLA-4 come nuova strategia di immunoterapia tumorale” e di “A novel synthesis of bioactive Dopa-peptidomimetics by biocatalytic processes”.
Bibliografia:
- Cerutti – I sostituti dello zucchero, in residui, additivi e contaminanti degli alimenti, Tecniche Nuove, 2006
- G. Renwick et al.- Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release, British Journal of Nutrition (2010), 104, 1415–1420
- Robino, N. Pirastu, P. Gasparini – La genetica del Gusto, Frontiere Luglio-Settembre 2014 • Vol. 44 • N. 175 • Pp. 197-202
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